J. Iwanejko, A. Brol, B.M. Szyja, M. Daszkiewicz, E. Wojaczyńska, T.K. Olszewski
Org. Biomol. Chem.
2019
17
7352-7359
New chiral tetrasubstituted aminophosphonic acid derivatives of hexahydroquinoxalin-2(1H)-one were synthesised via highly diastereoselective hydrophosphonylation of the corresponding imines with tris(trimethylsilyl) phosphite as phosphorus nucleophile. High asymmetric induction, good yields, mild reaction conditions, and ease of purification of the final products are the key advantages of the presented protocol.